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Translation Research

Translation Research

Part 1

Translational research aims to put scientific discoveries from fundamental or clinical investigations into practice. Faulty or biased clinical and translational research analysis can damage study participants and, as a result, the general community. While the drug trial participants are protected by institutional supervision authorities as embodied in federal rules, there is a lack of clear legal guidelines for high-impact assessments that do not directly affect the participants. The useUsingparticipants is always risky because logical flaws limit the likelihood of social gains (Gelfond, Heitman, Pollock & Klugman, 2011). On the other hand, uninterpretable analyses result in the waste of economic resources. Therefore, future research will likely be misdirected, hindering biomedical science development.

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Ethical and legal difficulties in translational research frequently arise in four areas: phases, gaps, information transfer, and the process itself. As a member of the translational research team, the first step in adhering to ethical and legal norms is to assess the potential consequences on subjects and the wider community. Translational research should not be confined to status or scientific curiosity but should consider how society will benefit (Grady, 2018). It is also critical that the researchers use a consequentialist approach to comprehensive reviewers associated with it. The researchers must guarantee a link between where the research is undertaken, by whom, the financing, subjects, and possible beneficiaries, while also taking vulnerable populations into account. This is a feature of social justice.

Part 2

The safety of the research subjects should be the top concern of all researchers. This can be accomplished by using all available information to detect potential dangers to the issues. They will then be needed to devise mitigating risks and continuously monitor the study to see if any adverse events would harm the participants (Koski, 2017). If substTheal investigator should be prepared to discontinue the trial.

If substantial unanticipated dangers emergevestigators must get informed consent from each individual selected to participate in the study. Individuals should be advised of the benefits and potential risks of participating in the study. It is recommended that informed permission be obtained in writing after participants have considered their participation’s potential risks and benefits Ulrich et al., 2012). They should be invited to ask any hot questions about the study, and responses should be supplied concisely. To protect the participants’ interests, informed consent should be continuous.

Furthermore, the investigator should place a high value on the subjects’ privacy and confidentiality. They should set safeguards to prevent disclosure and unauthorized access to information that could reveal the participant’s identity. Alternatively, plans must be implemented to deal with any adverse events that may arise due to the procedure. Justice requires treating all subjects in a study fairly, regardless of individual characteristics. The vulnerable populations taking part in the study must be given special consideration.

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Gelfond, J. A., Heitman, E., Pollock, B. H., & Klugman, C. M. (2011). Principles for the ethical analysis of clinical and translational research. Statistics in Medicine, 30(23), 2785-2792. doi:10.1002/sim.4282

Grady, C. (2018). Ethical Principles in Clinical Research. Principles and Practice of Clinical Research, pp. 19–31. doi:10.1016/b978-0-12-849905-4.00002-2

Koski, G. (2017). Ethical Issues in Translational Research and Clinical Investigation. Clinical and Translational Science, pp. 441–456. doi:10.1016/b978-0-12-802101-9.00024-7

Ulrich, C. M., Knafl, K. A., Ratcliffe, S. J., Richmond, T. S., Grady, C., Miller-Davis, C., & Wallen, G. R. (2012). Developing a Model of the Benefits and Burdens of Research Participation in Cancer Clinical Trials. AJOB Primary Research, 3(2), 10-23. doi:10.1080/21507716.2011.653472


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As a DNP, you are preparing a research project on assessing the effectiveness of evidence-based practice implementation in a healthcare organization’s man managing and substance use disorder. Address the following as it patterns to the project;

Translation Research

Translation Research

1. How do stakeholders describe and measure quality in this organization or functional
unit? Who ownsWhoe data?
2. What quality improvement activities are underway in the organization or functional
3. What are the quality goals of the group [or organization]?
4. Has the group [organization] been successful in its quality improvement efforts?

5. Have there been failures in work or quality improvement?

6. What are the baseline measures of quality before the project begins?
7. What is the level of quality below which performance must not fall?
8. How is benchmarking accomplished?
9. Who are the stakeholders?

Document this assignment in 2 pages Word document, including three references published in the last five years.

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